GLP-2 Vial

GLP-2 Vial: Research-Grade Dual GIP/GLP-1 Receptor Agonist

GLP-2 is the catalog name for a synthetic peptide that activates two incretin receptors at once: the glucose-dependent insulinotropic polypeptide receptor (GIPR) and the glucagon-like peptide-1 receptor (GLP-1R). Dual agonists of this kind are one of the most active areas of incretin and metabolic research.

Stacked BioLabs supplies GLP-2 as a lyophilized powder in 5 mg, 10 mg, 15 mg and 30 mg vials, each with a lot-specific certificate of analysis.

Compound identity

Research background

GIP and GLP-1 are the two main incretin hormones, released from the gut after a meal to amplify glucose-dependent insulin secretion. A dual agonist combines both signals in a single molecule. Peptides in this class are typically built on a GIP-based backbone with substitutions that add GLP-1 receptor activity, plus a fatty-diacid side chain that binds albumin and extends activity in research models to several days.

Research on dual GIP/GLP-1 agonism asks whether engaging both receptors produces effects beyond GLP-1 agonism alone on glucose control, food intake, energy balance and body composition. Pharmacology studies in this class also examine biased signaling at the GLP-1 receptor, with a preference for cAMP signaling over beta-arrestin recruitment, as a factor in receptor behaviour. A large clinical literature on dual incretin agonists supports this laboratory work.

In the catalog, GLP-2 sits between the single-receptor GLP-1 and the GIP/GLP-1/glucagon triple agonist GLP-3. For a small-molecule, non-peptide GLP-1R agonist, see orforglipron.

Verifying your lot

Every vial carries a lot number. Match it to its certificate in the COA & lab reports library, which lists identity and purity results for that specific batch. A certificate applies only to the lot it names. If you can’t find a report for your lot, contact us and we’ll supply it. Keep the certificate in your lab records together with the product, strength and lot number, so every result can be traced back to the exact batch used.

A typical certificate reports purity by high-performance liquid chromatography (HPLC) and confirms identity by mass spectrometry (MS), comparing the measured molecular mass with the expected value for the compound. Check that the product name, strength and lot number on the certificate match the label before recording results.

Storage and handling

Lyophilized peptides are most stable when kept cold, dry and away from light; −20 °C is the standard for long-term storage of lyophilized material. Follow the storage instructions supplied with the material and your institution’s handling procedures. Reconstitution is usually done with sterile or bacteriostatic water, depending on your protocol. Before opening, let the vial reach room temperature to limit condensation, and use sterile technique when puncturing the stopper. Label each reconstituted vial with the date, diluent and concentration used, and keep it refrigerated and protected from light.

Frequently asked questions

Further reading

1. PubMed literature on dual GIP/GLP-1 receptor agonists
2. PubMed literature on incretin biology