5-Amino-1MQ Capsules

5-Amino-1MQ Capsules: Capsule-Format NNMT Inhibitor for Metabolic Research

5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme concentrated in fat tissue that links nicotinamide, NAD+ recycling and the cell’s methyl-donor supply. This listing supplies it in pre-measured capsules for research designs that call for a capsule format.

Each bottle contains 60 capsules at 50 mg per capsule, with a lot-specific certificate of analysis.

Compound identity

Research background

As a small, charged quinolinium compound, 5-Amino-1MQ was selected from a series of NNMT inhibitors for its ability to enter cells. Its developers at the University of Texas Medical Branch reported that it raised intracellular NAD+ and S-adenosylmethionine in fat cells and suppressed lipogenesis, and that in mice on a high-fat diet it reduced body weight, fat-cell size and plasma cholesterol without reducing food intake.

Those findings put NNMT at the intersection of two research themes: NAD+ availability, which is central to sirtuin and mitochondrial research, and methylation capacity, which affects gene regulation. Later work has examined NNMT in muscle stem cells and aging muscle, where inhibiting the enzyme was associated with improved regenerative capacity in older mice.

Capsules suit studies that compare the capsule format with other formats or need consistent pre-measured amounts. The same compound is available in vials, and it is often researched alongside NAD+, SLU-PP-332 and BAM-15.

Verifying your lot

Every bottle carries a lot number. Match it to its certificate in the COA & lab reports library, which lists identity and purity results for that specific batch. A certificate applies only to the lot it names. If you can’t find a report for your lot, contact us and we’ll supply it. Keep the certificate in your lab records together with the product, strength and lot number, so every result can be traced back to the exact batch used.

A typical certificate reports purity by high-performance liquid chromatography (HPLC) and confirms identity by mass spectrometry (MS), comparing the measured molecular mass with the expected value for the compound. Check that the product name, strength and lot number on the certificate match the label before recording results.

Storage and handling

Keep the bottle tightly closed in a cool, dry place, away from light and moisture, and follow the storage instructions on the label. Record the lot number and the date the bottle is first opened so every use can be traced in your laboratory records. Do not transfer capsules into unlabeled containers, and keep the original bottle and its label with the material until the lot is used up or retired from your study.

Frequently asked questions

References

1. Neelakantan H, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochem Pharmacol. 2018. PubMed
2. Further reading: PubMed literature on 5-Amino-1MQ and NNMT